Welcome Reception and Super Bowl Party
4:00 pm-7:00 pm
Grand Ballroom

Symposia Topic 1: Modern Heterocyclic Construction
Victor Snieckus, Queen’s University, Chair
7:00 pm

Speakers: Part I

Amir Hoveyda, Boston College

"Catalytic Enantioselective and Practical Olefin Metathesis Reactions"

Jin K. Cha, University of Alabama

"New Synthetic Methods for Bioactive Heterocycles"

P. Andrew Evans, University of Delaware

"New Organometalice Mediated Cross-Coupling Reactions for the Construction of Complex Biologically Important Natural Products."

Continental Breakfast
7:30 am
Ballroom Foyer

Symposia Topic 1: Modern Heterocyclic Construction
Victor Snieckus, Queen’s University, Chair
8:00 am – 11:00 am
Mt. Werner/Sunshine Peak

Speakers: Part II

Ron Grigg, University of Leeds

"Catalytic Cascade Reactions: Routes to Potentially Bio-active Complex Heterocycles"

David J. Hart, Ohio State University

"New Wrinkles on Old Reactions in Heterocyclic Chemistry: Applications to Alkaloid Total Synthesis"

Victor Snieckus, Queen’s University

"Constructing Substituted Heterocycles: Comparing Directed ortho Metalation with Other Selected Methodologies"

Al Padwa, Emory University

"Cascade Processes for Heterocyclic Synthesis"

Poster Session 1
4:00pm – 5:00 pm
Storm Peak

Symposia Topic 2: Target-Driven Approaches to Anticancer Agents
Bryan H. Norman, Eli Lilly and Company, Chair
5:00pm – 8:00 pm
Mt. Werner/Sunshine Peak

Speakers:

Homer Pearce, Eli Lilly and Company

"Evolving Molecular Targets for Anticancer Drug Discovery"

Peter L. Toogood, Pfizer Global R&D

"Inhibition of Cyclin Dependent Kinases as an Approach to Cancer Therapy"

Louis Lombardo, Bristol-Myers Squibb

"The Discovery & Preclinical Development of Benzodiazepine Farnsey Itransferase Inhibitors"

Peter Traxler, Novartis Pharma. Ltd.

"Tyrosine kinase inhibitors-from rational design to clinical trials"

Continental Breakfast
7:30 am
Ballroom Foyer

Symposia Topic 3: Pharmacokinetics for Medicinal Chemists
David Lau, Amgen Inc., Chair
8:00 am – 11:00 am
Mt. Werner/Sunshine Peak

Speakers:

David Lau, Amgen Inc.

"Basic Pharmacokinetics Concepts for Medicinal Chemists in Drug Discovery Support"

Gondi Kumar, Amgen Inc.

"Metabolism Issues for Small Molecule Drug Discovery and Development"

2:00 pm – 3:30 pm
Hockey game at Howelson Arena

Symposia Topic 4: Recent Advances in the Structural Biology of Seven Transmembrane Receptors
Daniel Flynn, Millennium Pharmaceuticals, Inc., Chair
5:00 pm – 7:30 pm
Mt. Werner/Sunshine Peak

Speakers:

Thue Schwartz, University of Copenhagen

"State of the 7TMG-protein union – lessons from metal-ion site engineering and fusion proteins"

Dale Mierke, Brown University

"Peptide Hormone Binding to GPCR Receptors: Structural Characterization via NMR Techniques"

Oren Becker, Bio Information Technologies

"Modeling the 3D Structure of G-Protein Coupled Receptors from Primary Sequence"

General Papers
Mike VanNieuwenhze, Chair
8:00 am – 11:00 am
Mt. Werner/Sunshine Peak

11:30 am Mountain Lunch at Buddy’s Run, followed by group photo

2:00 pm NASTAR Race - NASTAR Race Course

Keynote Address
5:30 pm
Grand Ballroom
Dale Boger, Scripps Research Institute
"Vancomycin, Teicoplanin, and Ramoplanin: Synthetic & Mechanistic Studies"

Banquet
6:30 pm
Grand Ballroom

Dance
8:00 pm
Grand Ballroom

Continental Breakfast
7:30 am
Ballroom Foyer

Symposia Topic 5: Nuclear Hormone Receptors
Lawrence G. Hamann, Bristol-Myers Squibb, Chair

Speakers: Part I

A Brian Jones, Merck Research Laboratories

"New PPAR Modulators: Diabetes and Beyond"

Marcus F. Boehm, Ligand Pharm., Inc.

"Rexinoid Receptor Signalling Pathways as Targets for Drug Development"

Timothy M. Willson, Glaxo-Wellcome R&D

"Metabolic Regulation through Orphan Nuclear Receptors"

Poster Sessions 2
4:00 pm – 5:00 pm
Storm Peak

Symposia Topic 5: Nuclear Hormone Receptors
Lawrence G. Hamann, Bristol-Myers Squibb, Chair
5:00 pm – 7:30 pm
Mt. Werner and Sunshine Peak

Speakers: Part II

Jean-Marie Wurtz, IGBMC

"Ligand Specificity in RXR, RAR and VDR"

John A. Katzenellenbogen, University of Illinois

"Novel Ligands for Estrogen Receptor Alpha and Beta"

Donald P. McDonnell, Duke Univ. Medical Center

"Nuclear Receptor-Cofactor Interactions as Targets for New Drug Discovery"

Symposia Topic 6: Alkene Metathesis
Anthony G. M. Barrett, Imperial College, Chair
8:00 am – 12:00 noon
Mt. Werner/Sunshine Peak

Speakers:

Siegfried Blechert, Technische Universitat Berlin

"Sequential Olefin Metathesis—Applications in Natural Product Synthesis"

Anthony G.M. Barrett, Imperial College

"Alkene Metathesis: Applications from Small Moleculels to ROMPGELs"

Robert Grubbs, California Inst. of Technology

"The Use of Ruthenium Carbenes in Synthesis"

Friday noon conference adjournment